CAROLYN: 
I’m Carolyn, and I’m so much more than my breast cancer.

I’ve had many roles in my life. 
I’m a wife, a mother, a grandmother, a friend, a teacher. 
I have a husband of 44 years, three grown daughters, a grandchild, another grandchild on the way. 
I like to keep busy; I make a list every day.

I was worried when I retired that I might be bored, that I might not have enough things to fill my day… but that has not been the case. 
I like to read; I’m in a book club. 
I love swimming laps. 
Underwater it’s quiet, it’s peaceful. 
I see the sun sparkling on the surface—that’s when I say my prayers. 
I do things that make me feel alive.

So, when I was diagnosed with metastatic breast cancer, it stopped me in my tracks. 
I was concerned about how much time I would have. 
Will I be around for my children, my grandchildren? 
Will I be there for graduations and weddings and birthdays?

But then I realized, though my circumstances may have changed, I haven’t. 
And the things that matter to me haven’t changed either.
And once I started moving again, I started taking life slower, and now I don’t really miss a thing.  

Now, going to the doctor’s is just a part of my life, a part of my routine, and one of my daughters always goes with me.
We believe in my medical team, and we feel like they are part of our extended family.

I also believe in KISQALI. 
It’s working for me, and I trust it immensely.
It’s a once-a-day dose that I take in the morning, and it doesn’t get in the way of me being me.

Here’s the truth: there are good days, and there are hard days.
But I have a beautiful life! 
I get up every morning, and I remember that.

I used to get upset about things that bothered me,
But now I realize it doesn’t matter.
I’m definitely a more grateful person. 
And I’m very grateful that I’m able to do the things that I like to do and be with the people I love.

One of my greatest joys is rocking my granddaughter to sleep.
I love to just hold her, and look at her, and tell her what a wonderful world she’s been born into… what a wonderful life she has.

My overall approach to living with metastatic breast cancer is not to let it control me. 
I mean, it’s a part of me now, but it’s not who I am.
I’ve chosen to continue on, and I literally choose every single day to be happy.

VOICEOVER: 
What is KISQALI?

KISQALI® (ribociclib) is a prescription medicine used to treat adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer:

• in combination with an aromatase inhibitor for stage II and III early breast cancer with a high risk of coming back.
• that has gotten worse or has spread to other parts of the body (advanced or metastatic breast cancer) in combination with:
  • an aromatase inhibitor as the first endocrine-based therapy; or
  • fulvestrant as the first endocrine-based therapy or following disease progression on endocrine therapy

It is not known if KISQALI is safe and effective in children.

IMPORTANT SAFETY INFORMATION 
 
KISQALI may cause serious side effects, including:   
 
Lung problems. KISQALI may cause severe or life-threatening inflammation of the lungs during treatment that may lead to death. Tell your health care provider right away if you have any new or worsening symptoms, including:

• trouble breathing or shortness of breath   
• cough with or without mucus  
• chest pain

Severe skin reactions. Tell your health care provider or get medical help right away if you get severe rash or rash that keeps getting worse; reddened skin; flu-like symptoms; skin pain or burning, blistering of the lips, eyes, or mouth, blisters on the skin or skin peeling, with or without fever.   
 
Heart rhythm problems (QT prolongation). KISQALI can cause a heart problem known as QT prolongation. This condition can cause an abnormal heartbeat and may lead to death.

• Your health care provider should check your heart and do blood tests before and during treatment with KISQALI  
• Tell your healthcare provider right away if you have a change in your heartbeat (a fast or irregular heartbeat), or if you feel dizzy or faint 

Liver problems. KISQALI can cause serious liver problems. Your health care provider should do blood tests to check your liver before and during treatment with KISQALI. Tell your health care provider right away if you get any of the following signs and symptoms of liver problems:

• yellowing of your skin or the whites of your eyes (jaundice)  
• dark or brown (tea-colored) urine  
• feeling very tired  
• loss of appetite  
• pain on the upper right side of your stomach area (abdomen)
• bleeding or bruising more easily than normal

Low white blood cell counts (neutropenia). Low white blood cell counts are very common during treatment with KISQALI and may result in infections that may be severe. Your health care provider should check your white blood cell counts before and during treatment with KISQALI. Tell your health care provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills. 

Your health care provider may tell you to decrease your dose, temporarily stop, or completely stop taking KISQALI if you develop certain serious side effects during treatment with KISQALI.   
 
What should I tell my health care provider before taking KISQALI?  
 
Before you take KISQALI, tell your health care provider if you:  

• have any heart problems, including heart failure, irregular heartbeats, and QT prolongation  
• have ever had a heart attack  
• have a slow heartbeat (bradycardia)  
• have high blood pressure that is not controlled  
• have decreased thyroid gland function (hypothyroidism)  
• have problems with the amount of potassium, calcium, phosphorus, or magnesium in your blood  
• have fever, chills, or any other signs or symptoms of infection  
• have liver problems  
• have kidney problems  
• are pregnant, or plan to become pregnant. KISQALI can harm your unborn baby
  • If you are able to become pregnant, your health care provider should do a pregnancy test before you start treatment with KISQALI
  • Females who are able to become pregnant and who take KISQALI should use effective birth control during treatment and for at least 3 weeks after the last dose of KISQALI  
  • Talk to your health care provider about birth control methods that may be right for you during this time  
  • If you become pregnant or think you are pregnant, tell your health care provider right away  
• are breastfeeding or plan to breastfeed. It is not known if KISQALI passes into your breast milk. Do not breastfeed during treatment with KISQALI and for at least 3 weeks after the last dose of KISQALI

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. KISQALI and other medicines may affect each other, causing side effects. Know the medicines you take. Keep a list of them to show your health care provider or pharmacist when you get a new medicine.   
 
What should I avoid while taking KISQALI?   
 
Avoid eating grapefruit and avoid drinking grapefruit juice during treatment with KISQALI since these may increase the amount of KISQALI in your blood.   
 
The most common side effects of KISQALI in people with early breast cancer include:  

• decreased white blood cell counts  
• decreased red blood cell counts  
• increased liver function tests  
• infections  
• increased kidney function test  
• decreased platelet counts  
• nausea  
• headache  
• tiredness   

The most common side effects of KISQALI in people with advanced or metastatic breast cancer include:  

• decreased white blood cell counts  
• decreased red blood cell counts  
• increased liver function tests  
• infections  
• nausea  
• increased kidney function test  
• tiredness  
• decreased platelet counts  
• diarrhea  
• vomiting  
• headache  
• constipation  
• hair loss  
• cough  
• rash  
• back pain  
• low blood sugar level   

KISQALI may cause fertility problems in males, which may affect your ability to father a child. Talk to your health care provider if this is a concern for you.   
 
Tell your health care provider if you have any side effect that bothers you or that does not go away.   
 
These are not all the possible side effects of KISQALI. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.   
 
Please see full Prescribing Information, including Patient Information at KISQALI.com.

KATHY: 
I'm Kathy, and there's so much more to me than just breast cancer.

Ever since I was young, I've had to overcome adversity. 
I grew up in a very unstable household. 
We moved around all the time. 
My childhood taught me that I had to depend on myself and no one else.  

Books helped me escape.  
As a kid, I would go through three novels a week. 
When you read a novel, you have a hero in the novel. 
I needed heroes in my life. 
I think that reading as a child helped me decide to become a teacher. 
I also knew that there were children out there that needed someone that cared.

The day I learned that I had breast cancer was like an out-of-body experience. 
My biggest fear was losing my independence. 
I knew this was something I wasn't going to be able to do all by myself. 
That scared me more than death.

I had a lump in my breast taken out. 
I went through 45 treatments of radiation. 
I continued to teach.

The kids didn't know that I was going through breast cancer. 
I learned to leave my problems in the car. 
I didn't want them to have to be concerned about me.

As I went through the radiation, I thought everything was okay. 
So, when it came back, it had traveled to six places in my bone and my liver. 
I was panicked, and that's a fear that is beyond fear.

My granddaughter was about a year old then. 
I was afraid that I wasn't going to have any—much time with her.

With my oncologist, I found trust, and her confidence helped build my confidence. 
My oncologist and I talked about what we were planning on doing next.

KISQALI has been a major part of my treatment plan ever since. 
I like that KISQALI is a pill. 
I take it every day for three weeks, and then I get a week off. 
As I see it, KISQALI along with my aromatase inhibitor, it's doing its job. 
I'm very hopeful that KISQALI helps my cancer stay this way.

I'm retired now, and I still sub, and I've moved to another state to be closer to my daughter and granddaughter. 
Having a granddaughter is something so special, you can't even explain it to anybody. 
It's magic, and I love spending as much time with her as I can. 
She's smart, she's beautiful, she loves books. 
She's got some of my personality. 
I think a lot about the example I set for her. 
I try to teach her independence and standing up for herself and that it's okay to ask for help when you need it.

I realize how precious life is, and I want to continue to be here for my granddaughter. 
Because I have more lessons to teach, more things to learn, and a lot more to go.

VOICEOVER: 
What is KISQALI?

KISQALI® (ribociclib) is a prescription medicine used to treat adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer:

• in combination with an aromatase inhibitor for stage II and III early breast cancer with a high risk of coming back.
• that has gotten worse or has spread to other parts of the body (advanced or metastatic breast cancer) in combination with:
  • an aromatase inhibitor as the first endocrine-based therapy; or
  • fulvestrant as the first endocrine-based therapy or following disease progression on endocrine therapy

It is not known if KISQALI is safe and effective in children.

IMPORTANT SAFETY INFORMATION   
 
KISQALI may cause serious side effects, including:  

Lung problems. KISQALI may cause severe or life-threatening inflammation of the lungs during treatment that may lead to death. Tell your health care provider right away if you have any new or worsening symptoms, including:

• trouble breathing or shortness of breath   
• cough with or without mucus  
• chest pain 

Severe skin reactions. Tell your health care provider or get medical help right away if you get severe rash or rash that keeps getting worse; reddened skin; flu-like symptoms; skin pain or burning, blistering of the lips, eyes, or mouth, blisters on the skin or skin peeling, with or without fever.   
 
Heart rhythm problems (QT prolongation). KISQALI can cause a heart problem known as QT prolongation. This condition can cause an abnormal heartbeat and may lead to death.

• Your health care provider should check your heart and do blood tests before and during treatment with KISQALI  
• Tell your healthcare provider right away if you have a change in your heartbeat (a fast or irregular heartbeat), or if you feel dizzy or faint

Liver problems. KISQALI can cause serious liver problems. Your health care provider should do blood tests to check your liver before and during treatment with KISQALI. Tell your health care provider right away if you get any of the following signs and symptoms of liver problems:

• yellowing of your skin or the whites of your eyes (jaundice)  
• dark or brown (tea-colored) urine  
• feeling very tired  
• loss of appetite  
• pain on the upper right side of your stomach area (abdomen)
• bleeding or bruising more easily than normal    

Low white blood cell counts (neutropenia). Low white blood cell counts are very common during treatment with KISQALI and may result in infections that may be severe. Your health care provider should check your white blood cell counts before and during treatment with KISQALI. Tell your health care provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.   
 
Your health care provider may tell you to decrease your dose, temporarily stop, or completely stop taking KISQALI if you develop certain serious side effects during treatment with KISQALI.   
 
What should I tell my health care provider before taking KISQALI? 

Before you take KISQALI, tell your health care provider if you:

• have any heart problems, including heart failure, irregular heartbeats, and QT prolongation  
• have ever had a heart attack  
• have a slow heartbeat (bradycardia)  
• have high blood pressure that is not controlled  
• have decreased thyroid gland function (hypothyroidism)  
• have problems with the amount of potassium, calcium, phosphorus, or magnesium in your blood  
• have fever, chills, or any other signs or symptoms of infection
• have liver problems  
• have kidney problems  
• are pregnant, or plan to become pregnant. KISQALI can harm your unborn baby  
  • If you are able to become pregnant, your health care provider should do a pregnancy test before you start treatment with KISQALI  
  • Females who are able to become pregnant and who take KISQALI should use effective birth control during treatment and for at least 3 weeks after the last dose of KISQALI  
  • Talk to your health care provider about birth control methods that may be right for you during this time  
  • If you become pregnant or think you are pregnant, tell your health care provider right away  
• are breastfeeding or plan to breastfeed. It is not known if KISQALI passes into your breast milk. Do not breastfeed during treatment with KISQALI and for at least 3 weeks after the last dose of KISQALI

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. KISQALI and other medicines may affect each other, causing side effects. Know the medicines you take. Keep a list of them to show your health care provider or pharmacist when you get a new medicine.   
 
What should I avoid while taking KISQALI?   
 
Avoid eating grapefruit and avoid drinking grapefruit juice during treatment with KISQALI since these may increase the amount of KISQALI in your blood.   

The most common side effects of KISQALI in people with early breast cancer include:  

• decreased white blood cell counts  
• decreased red blood cell counts  
• increased liver function tests  
• infections  
• increased kidney function test  
• decreased platelet counts  
• nausea  
• headache  
• tiredness  

The most common side effects of KISQALI in people with advanced or metastatic breast cancer include:  
 

• decreased white blood cell counts  
• decreased red blood cell counts  
• increased liver function tests  
• infections  
• nausea  
• increased kidney function test  
• tiredness  
• decreased platelet counts
• diarrhea 
• vomiting 
• headache 
• constipation 
• hair loss 
• cough 
• rash 
• back pain 
• low blood sugar level
     

KISQALI may cause fertility problems in males, which may affect your ability to father a child. Talk to your health care provider if this is a concern for you.   
 
Tell your health care provider if you have any side effect that bothers you or that does not go away.   
 
These are not all the possible side effects of KISQALI. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
 
Please see full Prescribing Information, including Patient Information at KISQALI.com.

ANGELA:
I am from a little place called Menifee County, Kentucky.
It’s a little town… called Frenchburg, Kentucky. 
We don’t have a large population, but we have a lot of love in our community.
It’s a wonderful place to raise families, and it’s a wonderful place to live.

I am an elementary teacher. 
I teach the 4th grade language arts and writing.  
I have one of the greatest jobs in the world. 
I get to shape little minds. 
I get to meet all kinds of little new individuals every year.
And I get to be a part of their lives, and one of the most important people in their lives.

My journey started several years ago. 
Umm… for my 30th birthday, I was diagnosed with breast cancer.
I ended up with a double mastectomy, and radiation treatments, and also chemotherapy.

My breast cancer went into remission, and it had been in remission for several years. 
And then in 2021, they diagnosed me as stage 4.
That was, kind of surreal, but heartbreaking at the same time.

In your mind, you always know what stage 4 means. 
Stage 4 means, most of the time, that, you need to start making arrangements. 
I needed to make sure that everything was taken care of. 
But it was another part of the journey that we were going to have to go on.

From there, I met with the oncologist and that’s when he discussed the options that I would have.
Radiation was an option, but chemotherapy was not.
So, they had to immediately start me on radiation.

It was very hard on me. 
I had sores in my mouth; I couldn’t eat.
So that’s when we started discussing different treatments outside of the radiation.
I had to have something that would keep the tumors from spreading and keep them from enlarging.

And that’s when he started discussing this drug that they started using that was KISQALI.
Fortunately, we started on the KISQALI, and I think it has really been a game changer as far as for my life.

My tumors have not grown, they haven’t expanded, I haven’t gotten any new tumors. 
It has been something that did exactly what he had intended for it to do, was to help me to maintain. 
So, I’m still traveling this journey and, hopefully, I get to travel a lot longer.

I have a huge extra care team. 
I have my family, my husband, and my son, and my sister.
And I have a huge friend group and they are wonderful.

When I went back to school this year, they would call me and text me daily, “Are you feeling ok?” “Is everything all right?”
And make sure if I’m tired, “Well you need to rest.”
I can’t imagine that I could do this without them.

You build those relationships with those students and you are like their family. 
And when a member of their family has to take a leave, it affected the kids.
They all sent me letters and cards and telling me how much they missed me. 
And so, it was important to them, as well as myself, to get back to those kids that I loved so much.

If you would have asked me three years ago what I would say to someone who received the same diagnosis as myself, I would have said, “Oh, I’m so sorry, that’s horrible.” 
But now that I have been on this journey, and I see where it’s taking me, and I’ve gotten the results that I’ve gotten, I would honestly say to them…
“Don’t look at it as a life sentence. You can get treatment and still live every day a good life.”

Even with cancer, I enjoy life. 
I get to see and do the things that I love to do and I’m so grateful for that.

VOICEOVER: 
What is KISQALI?

KISQALI® (ribociclib) is a prescription medicine used to treat adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer: 

• in combination with an aromatase inhibitor for stage II and III early breast cancer with a high risk of coming back.

• that has gotten worse or has spread to other parts of the body (advanced or metastatic breast cancer) in combination with:
  • an aromatase inhibitor as the first endocrine-based therapy; or
  • fulvestrant as the first endocrine-based therapy or following disease progression on endocrine therapy

It is not known if KISQALI is safe and effective in children.

IMPORTANT SAFETY INFORMATION   
 
KISQALI may cause serious side effects, including:   
 
Lung problems. KISQALI may cause severe or life-threatening inflammation of the lungs during treatment that may lead to death. Tell your health care provider right away if you have any new or worsening symptoms, including:

• trouble breathing or shortness of breath   
• cough with or without mucus  
• chest pain

Severe skin reactions. Tell your health care provider or get medical help right away if you get severe rash or rash that keeps getting worse; reddened skin; flu-like symptoms; skin pain or burning, blistering of the lips, eyes, or mouth, blisters on the skin or skin peeling, with or without fever.

Heart rhythm problems (QT prolongation). KISQALI can cause a heart problem known as QT prolongation. This condition can cause an abnormal heartbeat and may lead to death.

• Your health care provider should check your heart and do blood tests before and during treatment with KISQALI  
• Tell your healthcare provider right away if you have a change in your heartbeat (a fast or irregular heartbeat), or if you feel dizzy or faint 

Liver problems. KISQALI can cause serious liver problems. Your health care provider should do blood tests to check your liver before and during treatment with KISQALI. Tell your health care provider right away if you get any of the following signs and symptoms of liver problems:

• yellowing of your skin or the whites of your eyes (jaundice)  
• dark or brown (tea-colored) urine  
• feeling very tired  
• loss of appetite  
• pain on the upper right side of your stomach area (abdomen)
• bleeding or bruising more easily than normal

Low white blood cell counts (neutropenia). Low white blood cell counts are very common during treatment with KISQALI and may result in infections that may be severe. Your health care provider should check your white blood cell counts before and during treatment with KISQALI. Tell your health care provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills. 

Your health care provider may tell you to decrease your dose, temporarily stop, or completely stop taking KISQALI if you develop certain serious side effects during treatment with KISQALI.   
 
What should I tell my health care provider before taking KISQALI?  
 
Before you take KISQALI, tell your health care provider if you:  

• have any heart problems, including heart failure, irregular heartbeats, and QT prolongation  
• have ever had a heart attack  
• have a slow heartbeat (bradycardia)  
• have high blood pressure that is not controlled  
• have decreased thyroid gland function (hypothyroidism)  
• have problems with the amount of potassium, calcium, phosphorus, or magnesium in your blood  
• have fever, chills, or any other signs or symptoms of infection  
• have liver problems  
• have kidney problems  
• are pregnant, or plan to become pregnant. KISQALI can harm your unborn baby
  • If you are able to become pregnant, your health care provider should do a pregnancy test before you start treatment with KISQALI
  • Females who are able to become pregnant and who take KISQALI should use effective birth control during treatment and for at least 3 weeks after the last dose of KISQALI  
  • Talk to your health care provider about birth control methods that may be right for you during this time  
  • If you become pregnant or think you are pregnant, tell your health care provider right away  
• are breastfeeding or plan to breastfeed. It is not known if KISQALI passes into your breast milk. Do not breastfeed during treatment with KISQALI and for at least 3 weeks after the last dose of KISQALI

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. KISQALI and other medicines may affect each other, causing side effects. Know the medicines you take. Keep a list of them to show your health care provider or pharmacist when you get a new medicine.   
 
What should I avoid while taking KISQALI?   
 
Avoid eating grapefruit and avoid drinking grapefruit juice during treatment with KISQALI since these may increase the amount of KISQALI in your blood.   
 
The most common side effects of KISQALI in people with early breast cancer include:  

• decreased white blood cell counts  
• decreased red blood cell counts  
• increased liver function tests  
• infections  
• increased kidney function test  
• decreased platelet counts  
• nausea  
• headache  
• tiredness   

The most common side effects of KISQALI in people with advanced or metastatic breast cancer include:  

• decreased white blood cell counts  
• decreased red blood cell counts  
• increased liver function tests  
• infections  
• nausea  
• increased kidney function test  
• tiredness  
• decreased platelet counts  
• diarrhea  
• vomiting  
• headache  
• constipation  
• hair loss  
• cough  
• rash  
• back pain  
• low blood sugar level   

KISQALI may cause fertility problems in males, which may affect your ability to father a child. Talk to your health care provider if this is a concern for you.   
 
Tell your health care provider if you have any side effect that bothers you or that does not go away.   
 
These are not all the possible side effects of KISQALI. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.   
 
Please see full Prescribing Information, including Patient Information at KISQALI.com.

LINDA: 
We were introduced at the Jewish Community Center swimming pool one hot day in the summer.

DAVID: 
I remember looking across the pool and seeing this statuesque athletic girl.
I was so taken with Linda.

LINDA: 
He was cute.
He offered to drive me home.
And when he pulled up in this gorgeous green convertible, I was smitten.

DAVID: 
At first, I had to compete with the car, but I think I won over, right?

LINDA: 
You did.
We have built this amazing life, with a variety of hobbies.

DAVID: 
Three great kids together.
We've had wonderful adventures.
But we've also had this very challenging adventure dealing with breast cancer on three separate events.
During those first two diagnoses, it was really quite a journey.

LINDA: 
After the lumpectomy radiation at age 35, I remember one of the doctors saying, “After five years, if you're clear, you're cured.”
That was very obviously not the case.

DAVID: 
Linda had cancer cells in multiple places and that’s just a very grave prognosis.
So, I was devastated because, as a physician, I realized that we might be grasping for straws. 
As a husband, all I wanted to do was to be supportive.

LINDA: 
Immediately, David took charge talking to other physicians, researching the best doctors, and finding the best treatment plan for me.

DAVID: 
I came across a drug called KISQALI.
And I said, “I think there may be hopeful treatments out there.” 
Linda’s first few blood tests after starting KISQALI, showed her blood cancer marker slowly coming down.
Her scans as of now show no active cancer disease whatsoever.

LINDA: 
I continue to live my life as fully as possible just doing what I love to do.

VOICEOVER: 
What is KISQALI?

KISQALI® (ribociclib) is a prescription medicine used to treat adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer: 

• in combination with an aromatase inhibitor for stage II and III early breast cancer with a high risk of coming back.

• that has gotten worse or has spread to other parts of the body (advanced or metastatic breast cancer) in combination with:
  • an aromatase inhibitor as the first endocrine-based therapy; or
  • fulvestrant as the first endocrine-based therapy or following disease progression on endocrine therapy

It is not known if KISQALI is safe and effective in children.

IMPORTANT SAFETY INFORMATION   
 
KISQALI may cause serious side effects, including:   
 
Lung problems. KISQALI may cause severe or life-threatening inflammation of the lungs during treatment that may lead to death. Tell your health care provider right away if you have any new or worsening symptoms, including:

• trouble breathing or shortness of breath   
• cough with or without mucus  
• chest pain

Severe skin reactions. Tell your health care provider or get medical help right away if you get severe rash or rash that keeps getting worse; reddened skin; flu-like symptoms; skin pain or burning, blistering of the lips, eyes, or mouth, blisters on the skin or skin peeling, with or without fever.   
 
Heart rhythm problems (QT prolongation). KISQALI can cause a heart problem known as QT prolongation. This condition can cause an abnormal heartbeat and may lead to death.

• Your health care provider should check your heart and do blood tests before and during treatment with KISQALI  
• Tell your healthcare provider right away if you have a change in your heartbeat (a fast or irregular heartbeat), or if you feel dizzy or faint 

Liver problems. KISQALI can cause serious liver problems. Your health care provider should do blood tests to check your liver before and during treatment with KISQALI. Tell your health care provider right away if you get any of the following signs and symptoms of liver problems:

• yellowing of your skin or the whites of your eyes (jaundice)  
• dark or brown (tea-colored) urine  
• feeling very tired  
• loss of appetite  
• pain on the upper right side of your stomach area (abdomen)
• bleeding or bruising more easily than normal

Low white blood cell counts (neutropenia). Low white blood cell counts are very common during treatment with KISQALI and may result in infections that may be severe. Your health care provider should check your white blood cell counts before and during treatment with KISQALI. Tell your health care provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills. 

Your health care provider may tell you to decrease your dose, temporarily stop, or completely stop taking KISQALI if you develop certain serious side effects during treatment with KISQALI.   
 
What should I tell my health care provider before taking KISQALI?  
 
Before you take KISQALI, tell your health care provider if you:  

• have any heart problems, including heart failure, irregular heartbeats, and QT prolongation  
• have ever had a heart attack  
• have a slow heartbeat (bradycardia)  
• have high blood pressure that is not controlled  
• have decreased thyroid gland function (hypothyroidism)  
• have problems with the amount of potassium, calcium, phosphorus, or magnesium in your blood  
• have fever, chills, or any other signs or symptoms of infection
• have liver problems  
• have kidney problems  
• are pregnant, or plan to become pregnant. KISQALI can harm your unborn baby
  • If you are able to become pregnant, your health care provider should do a pregnancy test before you start treatment with KISQALI
  • Females who are able to become pregnant and who take KISQALI should use effective birth control during treatment and for at least 3 weeks after the last dose of KISQALI  
  • Talk to your health care provider about birth control methods that may be right for you during this time  
  • If you become pregnant or think you are pregnant, tell your health care provider right away
• are breastfeeding or plan to breastfeed. It is not known if KISQALI passes into your breast milk. Do not breastfeed during treatment with KISQALI and for at least 3 weeks after the last dose of KISQALI

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. KISQALI and other medicines may affect each other, causing side effects. Know the medicines you take. Keep a list of them to show your health care provider or pharmacist when you get a new medicine.   
 
What should I avoid while taking KISQALI?   
 
Avoid eating grapefruit and avoid drinking grapefruit juice during treatment with KISQALI since these may increase the amount of KISQALI in your blood.   
 
The most common side effects of KISQALI in people with early breast cancer include:  

• decreased white blood cell counts  
• decreased red blood cell counts  
• increased liver function tests  
• infections  
• increased kidney function test  
• decreased platelet counts  
• nausea  
• headache  
• tiredness   

The most common side effects of KISQALI in people with advanced or metastatic breast cancer include:  

• decreased white blood cell counts  
• decreased red blood cell counts  
• increased liver function tests  
• infections  
• nausea  
• increased kidney function test  
• tiredness  
• decreased platelet counts  
• diarrhea  
• vomiting  
• headache  
• constipation  
• hair loss  
• cough  
• rash  
• back pain  
• low blood sugar level   

KISQALI may cause fertility problems in males, which may affect your ability to father a child. Talk to your health care provider if this is a concern for you.   
 
Tell your health care provider if you have any side effect that bothers you or that does not go away.   
 
These are not all the possible side effects of KISQALI. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.   
 
Please see full Prescribing Information, including Patient Information at KISQALI.com.

LISA: 
I will never forget when they told me my cancer came back.
I cried, and I cried.
I was a mess.

I had been cancer-free at that moment, five years.
I had a right-side mastectomy, lymph node removal, and chemotherapy.
I thought I was finished; I did not think the cancer was going to come back.
The cancer had metastasized to my brain, lungs, and bones.

When I pulled myself together, I had to remember that I’m not just a fighter, I'm not a survivor, I am an overcomer.
There are women who survive this and go on to live their lives.
I just made up my mind… I'm going to be one of them.

My oncologist told me that the type of metastatic breast cancer I had was HR-positive, HER2-negative, and that it was more treatable and not as aggressive as some of the other cancers out there.
That gave me hope.
Okay, we can treat it, let's go.
What's the plan? Let's get this done.

That's when we started talking about KISQALI as a treatment option.
KISQALI was different.

It was a pill I can take in combination with fulvestrant and other medications that my doctor prescribed.
I would take 3 pills a day for three weeks on, and I would get a break for a week.
So, it's three weeks on, one week off.
I said, “A break? Absolutely! I like breaks.”

I started my first treatment 3 weeks after my diagnosis.
So far, I'm able to tolerate the side effects pretty well.
Sometimes I have dry skin, loss of appetite.
When I'm taking the medication, I eat enough food when I take it so that combats any kind of nausea that I may have.
I mainly deal with fatigue.
On the days when I'm really tired, I listen to my body and rest.

Six months after starting KISQALI, I had my first PET scan.
And that PET scan showed that my tumor markers were shrinking.
I was ecstatic.

I called my friends and family.
I said look this medication is working, we're going to celebrate tonight. 
Come on over!
I started taking KISQALI in 2020, and I intend to keep taking it as long as it keeps working for me.

I have so much going on in my life.
I'm a legal assistant, I am a travel agent, I am a minister, I'm a grandmother.
I love doing all of these things and it's very important that I'm able to keep going and doing all those things.

A lot of the time I feel good, I have energy, I'm able to get up and move and go.
I'm not always sick.
I remind myself often that I may have cancer, but cancer does not have me.
I look at metastatic breast cancer as a chronic condition that I live with, and that I can manage.

My focus today is on living and spending quality time with my grandchildren and travelling. 
The world is big, and I'm planning on seeing as much of it as possible.

I’m of the belief that life is a gift, and every day that you have been given is a chance to show up for yourself.
Live your day, live your life.
Open up your day and see what it’s full of and enjoy it.

VOICEOVER: 
What is KISQALI?

KISQALI® (ribociclib) is a prescription medicine used to treat adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer: 

• in combination with an aromatase inhibitor for stage II and III early breast cancer with a high risk of coming back.

• that has gotten worse or has spread to other parts of the body (advanced or metastatic breast cancer) in combination with:
  • an aromatase inhibitor as the first endocrine-based therapy; or
  • fulvestrant as the first endocrine-based therapy or following disease progression on endocrine therapy

It is not known if KISQALI is safe and effective in children.

IMPORTANT SAFETY INFORMATION   
 
KISQALI may cause serious side effects, including:   
 
Lung problems. KISQALI may cause severe or life-threatening inflammation of the lungs during treatment that may lead to death. Tell your health care provider right away if you have any new or worsening symptoms, including:

• trouble breathing or shortness of breath   
• cough with or without mucus  
• chest pain

Severe skin reactions. Tell your health care provider or get medical help right away if you get severe rash or rash that keeps getting worse; reddened skin; flu-like symptoms; skin pain or burning, blistering of the lips, eyes, or mouth, blisters on the skin or skin peeling, with or without fever.   
 
Heart rhythm problems (QT prolongation). KISQALI can cause a heart problem known as QT prolongation. This condition can cause an abnormal heartbeat and may lead to death.

• Your health care provider should check your heart and do blood tests before and during treatment with KISQALI  
• Tell your healthcare provider right away if you have a change in your heartbeat (a fast or irregular heartbeat), or if you feel dizzy or faint 

Liver problems. KISQALI can cause serious liver problems. Your health care provider should do blood tests to check your liver before and during treatment with KISQALI. Tell your health care provider right away if you get any of the following signs and symptoms of liver problems:

• yellowing of your skin or the whites of your eyes (jaundice)  
• dark or brown (tea-colored) urine  
• feeling very tired  
• loss of appetite  
• pain on the upper right side of your stomach area (abdomen)
• bleeding or bruising more easily than normal

Low white blood cell counts (neutropenia). Low white blood cell counts are very common during treatment with KISQALI and may result in infections that may be severe. Your health care provider should check your white blood cell counts before and during treatment with KISQALI. Tell your health care provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills. 

Your health care provider may tell you to decrease your dose, temporarily stop, or completely stop taking KISQALI if you develop certain serious side effects during treatment with KISQALI.   
 
What should I tell my health care provider before taking KISQALI?  
 
Before you take KISQALI, tell your health care provider if you:  

• have any heart problems, including heart failure, irregular heartbeats, and QT prolongation  
• have ever had a heart attack  
• have a slow heartbeat (bradycardia)  
• have high blood pressure that is not controlled  
• have decreased thyroid gland function (hypothyroidism)  
• have problems with the amount of potassium, calcium, phosphorus, or magnesium in your blood  
• have fever, chills, or any other signs or symptoms of infection  
• have liver problems  
• have kidney problems  
• are pregnant, or plan to become pregnant. KISQALI can harm your unborn baby
  • If you are able to become pregnant, your health care provider should do a pregnancy test before you start treatment with KISQALI
  • Females who are able to become pregnant and who take KISQALI should use effective birth control during treatment and for at least 3 weeks after the last dose of KISQALI  
  • Talk to your health care provider about birth control methods that may be right for you during this time  
  • If you become pregnant or think you are pregnant, tell your health care provider right away
• are breastfeeding or plan to breastfeed. It is not known if KISQALI passes into your breast milk. Do not breastfeed during treatment with KISQALI and for at least 3 weeks after the last dose of KISQALI

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. KISQALI and other medicines may affect each other, causing side effects. Know the medicines you take. Keep a list of them to show your health care provider or pharmacist when you get a new medicine.   
 
What should I avoid while taking KISQALI?   
 
Avoid eating grapefruit and avoid drinking grapefruit juice during treatment with KISQALI since these may increase the amount of KISQALI in your blood.   
 
The most common side effects of KISQALI in people with early breast cancer include:  

• decreased white blood cell counts  
• decreased red blood cell counts  
• increased liver function tests  
• infections  
• increased kidney function test  
• decreased platelet counts  
• nausea  
• headache  
• tiredness   

The most common side effects of KISQALI in people with advanced or metastatic breast cancer include:  

• decreased white blood cell counts  
• decreased red blood cell counts  
• increased liver function tests  
• infections  
• nausea  
• increased kidney function test  
• tiredness  
• decreased platelet counts  
• diarrhea  
• vomiting  
• headache  
• constipation  
• hair loss  
• cough  
• rash  
• back pain  
• low blood sugar level   

KISQALI may cause fertility problems in males, which may affect your ability to father a child. Talk to your health care provider if this is a concern for you.   
 
Tell your health care provider if you have any side effect that bothers you or that does not go away.   
 
These are not all the possible side effects of KISQALI. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.   
 
Please see full Prescribing Information, including Patient Information at KISQALI.com.