How to Take KISQALI


icon-dotdropsHow to Take KISQALI

KISQALI® (ribociclib) tablets is a once-daily oral tablet that is prescribed with an oral hormone therapy (eg, letrozole or anastrozole) or with fulvestrant, an injection administered by your health care provider. It is important to follow your doctor's directions on how to take KISQALI.

Recommended Dosing

For the first 3 weeks in a cycle, you’ll take your 3 KISQALI pills in combination with a hormone therapy. The fourth week, you won’t take any KISQALI pills—you’ll only take your hormone therapy. After the fourth week, your doctor may have you start the same cycle over again, or may adjust your dose if needed.

  • The recommended starting dose of KISQALI is 600 mg (three 200-mg tablets), taken once daily
  • Ask your doctor about the recommended dose of your hormone therapy
KISQALI + hormone therapy dosing

Recommended Dosing

KISQALI is taken orally on a 4-week dosing cycle. For the first 3 weeks in a cycle, you’ll take your 3 KISQALI pills once daily. On the fourth week, you won’t take any KISQALI pills. Your doctor may adjust your dose if needed. Fulvestrant is an injection administered by your health care provider, taken in combination with KISQALI.

KISQALI + fulvestrant dosing

icon-dosingDosing Instructions 

  • Take the recommended dose of KISQALI® (ribociclib) once each day at about the same time, preferably in the morning
  • You can take KISQALI either with or without food
  • Swallow KISQALI tablets whole with a glass of water. Do not chew, crush, or split the tablets
  • Do not take any KISQALI tablets that are broken, cracked, or that look damaged
  • Avoid grapefruit and grapefruit juice while taking KISQALI
  • If you miss a dose of KISQALI or vomit after taking a dose of KISQALI, do not take another dose on that day. Take your next dose at your regular time
  • If you take too much KISQALI, call your doctor right away or go to the nearest hospital emergency room

icon-dotdropsDose Adjustments

KISQALI® (ribociclib) offers dosing flexibility to help your doctor find the dose of KISQALI that’s right for you. Your doctor may lower your dose, interrupt your dose, or stop treatment with KISQALI to help you manage side effects.


Reducing KISQALI tabletsKISQALI dosing can easily be adjusted by your doctor to fit your needs. If your doctor decides that you need a lower dose, you won't need to obtain a new prescription to adjust your dose that month.


The number of 200-mg tablets may be reduced from 3 tablets to 2 tablets to 1 tablet, according to your doctor's instructions. 


Do not change your dose or stop taking KISQALI unless your doctor tells you to do so.