How to Take KISQALI


Chart showing the recommended dosing schedule for KISQALI, NSAI when taken with KISQALI, and Fulvestrant when taken with KISQALI


KISQALI® (ribociclib) is a once-daily oral tablet that is prescribed with an oral nonsteroidal aromatase inhibitor (NSAI) (eg letrozole or anastrozole) or with fulvestrant, an injection administered by your health care provider. It is important to follow your doctor's directions on how to take KISQALI.

Recommended Dosing

KISQALI is taken on a 4-week dosing cycle. For the first 3 weeks in a cycle, you'll take KISQALI once daily. On the fourth week, you won't take any KISQALI pills. If you're taking an oral NSAI, you'll take it with KISQALI for the first 3 weeks, and alone for the fourth week. If you're receiving fulvestrant, talk to your doctor about your injection schedule.

Recommended Dosing for KISQALI, NSAI when taken with KISQALI, and Fulvestrant when taken with KISQALI

Dosing InstructionsDosing Instructions 

  • Take the recommended dose of KISQALI® (ribociclib) once each day at about the same time, preferably in the morning
  • You can take KISQALI either with or without food
  • Swallow KISQALI tablets whole with a glass of water. Do not chew, crush, or split the tablets
  • Do not take any KISQALI tablets that are broken, cracked, or that look damaged
  • Avoid grapefruit and grapefruit juice while taking KISQALI
  • If you miss a dose of KISQALI or vomit after taking a dose of KISQALI, do not take another dose on that day. Take your next dose at your regular time
  • If you take too much KISQALI, call your doctor right away or go to the nearest hospital emergency room