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Signs & Symptoms

HR+, HER2- Metastatic Breast Cancer

Signs and Symptoms Signs and Symptoms

Advanced (Metastatic) Breast Cancer Symptoms

Up to 30% of people who have been diagnosed with early-stage breast cancer may eventually develop stage 4 metastatic breast cancer, or advanced breast cancer, and while early-stage symptoms like lumps in the breast or changes in breast appearance can be detected through a self-exam, breast cancer symptoms can become more difficult to detect once the cancer has advanced and metastasized in other parts of the body.


There are certain signs and symptoms of advanced breast cancer to be aware of, and they can vary depending on where cancer is located. It's important to understand where advanced breast cancer can spread to in the body. The information below may help.


Breast cancer most commonly spreads to:

icon-joint The bones
• Severe pain that gets worse 
• Swelling 
• Bones that easily break

icon-liverThe liver
• Yellowing of the skin or eyes (jaundice) 
• Itchy skin or rash 
• Abnormally high liver enzyme levels 
• Stomach pain, loss of appetite, nausea, or vomiting

icon-lungsThe lungs
• Chronic cough 
• Shortness of breath 
• Chest pain 
• Abnormal chest x-ray

icon-brainThe brain
• Constant headaches that get worse 
• Vision problems 
• Seizures 
• Nausea or vomiting 
• Behavior or personality changes

If you’ve recently been diagnosed with metastatic breast cancer, it’s important to know that you’re not alone. There are many women, just like you, who are determined to continue living as fully as possible.