For US residents only.

Signs & Symptoms

HR+, HER2- Metastatic Breast Cancer

HR+, HER2- Metastatic Breast Cancer Symptoms

Advanced (Metastatic) Breast Cancer Symptoms

Up to 30% of people who have been diagnosed with early-stage breast cancer may eventually develop stage 4 metastatic breast cancer, (mBC) or advanced breast cancer, and while early-stage symptoms like lumps in the breast or change in breast appearance can be detected through a self-exam, breast cancer symptoms can become more difficult to detect once the cancer has advanced and metastasized in other parts of the body.


Approximately 5–9% of women who are diagnosed with breast cancer for the first time are diagnosed with mBC at the time of initial diagnosis. Approximately 20–30% of women initially diagnosed with early-stage disease will eventually develop metastatic breast cancer.


There are certain signs and symptoms of advanced breast cancer to be aware of, and they can vary depending on where cancer is located. It's important to understand where advanced breast cancer can spread to in the body. The information below may help.


Common areas where breast cancer spreads:

icon-joint The bones
• Severe pain that gets worse 
• Swelling 
• Bones that easily break

icon-liverThe liver
• Yellowing of the skin or eyes (jaundice) 
• Itchy skin or rash 
• Abnormally high liver enzyme levels 
• Stomach pain, loss of appetite, nausea, or vomiting

icon-lungsThe lungs
• Chronic cough 
• Shortness of breath 
• Chest pain 
• Abnormal chest x-ray

If you’ve recently been diagnosed with metastatic breast cancer, it’s important to know that you’re not alone. There are many women, just like you, who are determined to continue living as fully as possible.